DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans.
Identifieur interne : 003134 ( Main/Exploration ); précédent : 003133; suivant : 003135DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans.
Auteurs : Sheng-Fan Wang [Taïwan] ; Jason C. Huang ; Yuan-Ming Lee ; Shih-Jen Liu ; Yu-Jiun Chan ; Yat-Pang Chau ; Pele Chong ; Yi-Ming Arthur ChenSource :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Chiens, Conformation des protéines, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (transmission), Grippe humaine (immunologie), Grippe humaine (transmission), Humains, Hémagglutination virale (immunologie), Lectines de type C (immunologie), Lignée cellulaire, Molécules d'adhérence cellulaire (immunologie), Protéines virales (immunologie), Récepteurs de surface cellulaire (immunologie), Sialidase (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Virion (génétique), Virion (immunologie), Volaille (immunologie), Volaille (virologie).
- MESH :
- génétique : Sous-type H5N1 du virus de la grippe A, Virion.
- immunologie : Cellules dendritiques, Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Grippe humaine, Hémagglutination virale, Lectines de type C, Molécules d'adhérence cellulaire, Protéines virales, Récepteurs de surface cellulaire, Sialidase, Sous-type H5N1 du virus de la grippe A, Virion, Volaille.
- virologie : Cellules dendritiques, Volaille.
- Animaux, Anticorps monoclonaux, Chiens, Conformation des protéines, Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Grippe humaine, Humains, Lignée cellulaire.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Cell Adhesion Molecules (immunology), Cell Line, Dendritic Cells (immunology), Dendritic Cells (virology), Dogs, Hemagglutination, Viral (immunology), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza in Birds (immunology), Influenza in Birds (transmission), Influenza, Human (immunology), Influenza, Human (transmission), Lectins, C-Type (immunology), Neuraminidase (immunology), Poultry (immunology), Poultry (virology), Protein Conformation, Receptors, Cell Surface (immunology), Viral Proteins (immunology), Virion (genetics), Virion (immunology).
- MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Cell Adhesion Molecules, Hemagglutinin Glycoproteins, Influenza Virus, Lectins, C-Type, Neuraminidase, Receptors, Cell Surface, Viral Proteins.
- chemical : Antibodies, Monoclonal.
- genetics : Influenza A Virus, H5N1 Subtype, Virion.
- immunology : Dendritic Cells, Hemagglutination, Viral, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Influenza, Human, Poultry, Virion.
- transmission : Influenza in Birds, Influenza, Human.
- virology : Dendritic Cells, Poultry.
- Animals, Cell Line, Dogs, Humans, Protein Conformation.
Abstract
DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their ability to bind with DC-SIGN. Electronic microscopy and functional assay results indicate that pseudotyped viruses containing both HA and NA proteins express hemagglutination and are capable of infecting cells expressing alpha-2,3-linked sialic acid receptors. Results from a capture assay show that DC-SIGN-expressing cells (including B-THP-1/DC-SIGN and T-THP-1/DC-SIGN) and peripheral blood dendritic cells are capable of transferring H5N1 pseudotyped and RG virus particles to target cells; this action can be blocked by anti-DC-SIGN monoclonal antibodies. In summary, (a) DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and (b) DC-SIGN mediates infections in cis and in trans.
DOI: 10.1016/j.bbrc.2008.06.078
PubMed: 18593570
Affiliations:
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Huang</name></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name></author><author><name sortKey="Liu, Shih Jen" sort="Liu, Shih Jen" uniqKey="Liu S" first="Shih-Jen" last="Liu">Shih-Jen Liu</name></author><author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name></author><author><name sortKey="Chau, Yat Pang" sort="Chau, Yat Pang" uniqKey="Chau Y" first="Yat-Pang" last="Chau">Yat-Pang Chau</name></author><author><name sortKey="Chong, Pele" sort="Chong, Pele" uniqKey="Chong P" first="Pele" last="Chong">Pele Chong</name></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18593570</idno><idno type="pmid">18593570</idno><idno type="doi">10.1016/j.bbrc.2008.06.078</idno><idno type="wicri:Area/PubMed/Corpus">001B09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B09</idno><idno type="wicri:Area/PubMed/Curation">001B09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B09</idno><idno type="wicri:Area/PubMed/Checkpoint">001B62</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B62</idno><idno type="wicri:Area/Ncbi/Merge">001C91</idno><idno type="wicri:Area/Ncbi/Curation">001C91</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C91</idno><idno type="wicri:Area/Main/Merge">003228</idno><idno type="wicri:Area/Main/Curation">003134</idno><idno type="wicri:Area/Main/Exploration">003134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans.</title><author><name sortKey="Wang, Sheng Fan" sort="Wang, Sheng Fan" uniqKey="Wang S" first="Sheng-Fan" last="Wang">Sheng-Fan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Laboratory Science in Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biotechnology and Laboratory Science in Medicine, School of Medicine, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jason C" sort="Huang, Jason C" uniqKey="Huang J" first="Jason C" last="Huang">Jason C. Huang</name></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name></author><author><name sortKey="Liu, Shih Jen" sort="Liu, Shih Jen" uniqKey="Liu S" first="Shih-Jen" last="Liu">Shih-Jen Liu</name></author><author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name></author><author><name sortKey="Chau, Yat Pang" sort="Chau, Yat Pang" uniqKey="Chau Y" first="Yat-Pang" last="Chau">Yat-Pang Chau</name></author><author><name sortKey="Chong, Pele" sort="Chong, Pele" uniqKey="Chong P" first="Pele" last="Chong">Pele Chong</name></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Cell Adhesion Molecules (immunology)</term><term>Cell Line</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (virology)</term><term>Dogs</term><term>Hemagglutination, Viral (immunology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (transmission)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (transmission)</term><term>Lectins, C-Type (immunology)</term><term>Neuraminidase (immunology)</term><term>Poultry (immunology)</term><term>Poultry (virology)</term><term>Protein Conformation</term><term>Receptors, Cell Surface (immunology)</term><term>Viral Proteins (immunology)</term><term>Virion (genetics)</term><term>Virion (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Cellules dendritiques (immunologie)</term><term>Cellules dendritiques (virologie)</term><term>Chiens</term><term>Conformation des protéines</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe chez les oiseaux (transmission)</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (transmission)</term><term>Humains</term><term>Hémagglutination virale (immunologie)</term><term>Lectines de type C (immunologie)</term><term>Lignée cellulaire</term><term>Molécules d'adhérence cellulaire (immunologie)</term><term>Protéines virales (immunologie)</term><term>Récepteurs de surface cellulaire (immunologie)</term><term>Sialidase (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (génétique)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Virion (génétique)</term><term>Virion (immunologie)</term><term>Volaille (immunologie)</term><term>Volaille (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cell Adhesion Molecules</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Lectins, C-Type</term><term>Neuraminidase</term><term>Receptors, Cell Surface</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="genetics" 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Human</term><term>Poultry</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Volaille</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dendritic Cells</term><term>Poultry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Dogs</term><term>Humans</term><term>Protein Conformation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Chiens</term><term>Conformation des protéines</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Humains</term><term>Lignée cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their ability to bind with DC-SIGN. Electronic microscopy and functional assay results indicate that pseudotyped viruses containing both HA and NA proteins express hemagglutination and are capable of infecting cells expressing alpha-2,3-linked sialic acid receptors. Results from a capture assay show that DC-SIGN-expressing cells (including B-THP-1/DC-SIGN and T-THP-1/DC-SIGN) and peripheral blood dendritic cells are capable of transferring H5N1 pseudotyped and RG virus particles to target cells; this action can be blocked by anti-DC-SIGN monoclonal antibodies. In summary, (a) DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and (b) DC-SIGN mediates infections in cis and in trans.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name><name sortKey="Chau, Yat Pang" sort="Chau, Yat Pang" uniqKey="Chau Y" first="Yat-Pang" last="Chau">Yat-Pang Chau</name><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name><name sortKey="Chong, Pele" sort="Chong, Pele" uniqKey="Chong P" first="Pele" last="Chong">Pele Chong</name><name sortKey="Huang, Jason C" sort="Huang, Jason C" uniqKey="Huang J" first="Jason C" last="Huang">Jason C. Huang</name><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><name sortKey="Liu, Shih Jen" sort="Liu, Shih Jen" uniqKey="Liu S" first="Shih-Jen" last="Liu">Shih-Jen Liu</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Wang, Sheng Fan" sort="Wang, Sheng Fan" uniqKey="Wang S" first="Sheng-Fan" last="Wang">Sheng-Fan Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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